The importance of PDGF signaling is underscored in genetically engineered rodent gliomas, where overproduction of human PDGFb ligand is sufficient to induce gliomagenesis in a dose-dependent manner and allows to recapitulate the histologic, etiologic and pathobiologic character of the PDGF subset of human gliomas [14], [15]. The gene discussed is PDGFB; the disease is central nervous system cancer.