MGMT and glioblastoma: Given that the status of MGMT and IDH genes are central in the treatment and/or prognosis of glioblastoma tumors [32], we investigated the methylation status of the MGMT gene and the presence of stereotypical mutations of IDH genes in the T98G, U-87 and IMR90 cell lines that were used in the RNA interference experiments (Additional File 3).