VEGFA and vascular neoplasm: Excess VEGF-A expression in skeletal muscle results in the induction of vascular tumors (hemangiomas) [12-14], whereas loss of VEGF-A activity due to increased production of its natural antagonist, sFlt-1 (soluble VEGF receptor-1/sVEGFR-1), as in preeclampsia, reduces angiogenesis [15].