BTK and rheumatoid arthritis: In combination with the in vitro studies with human primary cells, these results suggest that the effects of PCI-32765, a potent Btk inhibitor with demonstrated activity in NHL (non-Hodgkin's lymphoma) patients, has effects on multiple cell types that contribute to the pathogenesis of RA, and is highly effective in several inflammatory disease models including CIA, CAIA, RPA, and PCA.