He had a stage IVB chemorefractory end-stage SS with high blood burden of CD4+/CD7 tumor cells, BM involvement, multicentric nodal disease (bilateral axillary and inguinal, intercavoaortic, lomboaortic) (Fig. 1A) and highly symptomatic disseminated desquamating erythroderma with patch-like skin lesions, palmar fissuring and intense, disabling itching. The gene discussed is CD7; the disease is synovial sarcoma.