Interestingly, dysregulated TFH cell function has been reported in patients with lymphoma, such as angioimmunoblastic-T-cell lymphomas (AITL), and primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma (CSTCL) and autoimmune diseases, such as systemic lupus erythematosus (SLE) [17], [18], [19]. This evidence concerns the gene CD4 and angioimmunoblastic T-cell lymphoma.