BRCA1 and breast neoplasm: Although the sample number under study was relatively low (n = 7 BRCA mutant tumours vs. n = 15 non BRCA mutant tumours) comparison of the Capan-1 data with data from BRCA2 mutant primary breast tumours and BRCA1 mutant primary breast tumours and cell lines did suggest a trend for BRCA deficient samples to exhibit larger numbers of structural rearrangements, (median number for BRCA mutant tumours  = 72 rearrangements, median number for non-BRCA mutant tumours  =  41; Fig. 1C), consistent with the roles of BRCA1 and BRCA2 in maintaining genomic stability.