Overexpression of the anti-apoptotic B-cell lymphoma (Bcl-2) protein is common in CLL (Pepper et al, 1997, 1998) because of hypomethylation of the promoter region of the Bcl-2 gene (Hanada et al, 1993; Pepper et al, 2008) or because of a lack of expression of miR-15a and miR-16-1, which regulate Bcl-2 at the posttranscriptional level (Cimmino et al, 2005). This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.