We found no significant reduction of lung cancer risk in patients with over 1 year use of COX2 inhibitors, although there was some indication of a decreased risk (OR 0.79, 95% CI 0.65–0.95), in contrast to a very small study reporting a 60% reduction for COX2 inhibitor use of 2 years or more (Harris et al, 2007) (22 cases) with inevitable recall bias. This evidence concerns the gene PTGS2 and lung carcinoma.