ERBB2 and breast carcinoma: In conclusion, this study highlights another possible proof-of-principle of immune modulation by the trastuzumab–taxane combination in HER2-overexpressing breast carcinoma, and suggests that T-bet induction or the presence of T-bet+ lymphocytes in intratumoral lymphoid structures after neoadjuvant chemotherapy could be a new biomarker of the long-term efficacy of this regimen, which could help to select high-risk patients for additional therapies after neoadjuvant chemotherapy.