A list of the most significant upregulated and downregulated mRNAs is shown in Supplementary Tables 1A and B. Among the genes whose mRNA expression was upregulated in GEF-R and ERL-R CALU-3, there were vimentin, caveolin, HIF-1α and VEGF-B, which are generally correlated to a more invasive cancer cell phenotype. The gene discussed is HIF1A; the disease is cancer.