PTGS2 and neoplasm: In this study, we evaluated the in vitro and in vivo growth inhibitory effects of three different Cox-2 inhibitors, etodolac, celecoxib and NS-398 on three human bladder cancer cell lines, T24, 5637 and KK47, and we examined whether Cox-2 inhibitors could reverse the EMT in order to identify the mechanism of action for Cox-2 inhibitors as anti-tumour agents.