IL6R and systemic-onset juvenile idiopathic arthritis: Although methotrexate and tumor necrosis factor antagonists, such as infliximab, are often only partially effective against sJIA, the anti-interleukin 6 receptor antagonist tocilizumab or IL-1 receptor antagonist anakinra have shown good clinical efficacy in small open-label studies of sJIA and adult Still's Disease [11-14].