On the other hand, increased dietary fat in mice is well known to lead not only to obesity and increased adiposity, but also to several metabolic sequelae, such as insulin resistance, dyslipidemia and increased expression in hepatocytes of sterol regulatory element binding protein 1c (SREBP-1c), and of its target proteins acetyl-CoA-carboxylase-1 (ACC1) and fatty acid synthase (FAS), with subsequent enhanced hepatic de novo lipid biosynthesis [28]. Here, ACACA is linked to obesity due to melanocortin 4 receptor deficiency.