Instead, the HF diet-induced increase of OEA levels and decrease in 2-AG levels might be explained by our previous finding [28] that this dietary regimen: 1) on the one hand, increases the expression of both CD36 and stearoyl-CoA desaturase, two proteins involved in the uptake and biosynthesis, respectively, of oleic acid, the ultimate precursor of OEA; and 2) on the other hand, increases also the expression of the monoacylglycerol lipase, the major enzyme involved in 2-AG degradation. This evidence concerns the gene SCD and hydrops fetalis.