Polymorphisms in the adiponectin gene have also been shown to correlate with adiponectin plasma levels, The genotypes rs266729 C/C, rs1501299 T/T, and rs2241766 G/G were respectively associated with decreased adiponectin plasma levels [20,21], suggesting that these polymorphisms may be associated with increased risk of developing CRC. Here, ADIPOQ is linked to colorectal carcinoma.