To evaluate the signal transduction pathways involved in the IL-17-mediated RAGE induction, RA-FLS were pretreated with 20 μM LY294002, 50 μM AG490, 10 μM SB203580, 1 μM PD98059, 10 μM parthenolide, or 10 μM curcumin, and the IL-17 induction of RAGE was evaluated. The gene discussed is AGER; the disease is rheumatoid arthritis.