Altered vascular homeostasis observed in late stage of DN is characterized by both defective angiogenic factors, namely, VEGF, VEGFR1, endothelial progenitor cells, and angiopoietin 1, as well as abnormally elevated antiangiogenic factors, namely, VEGFR2 and angiopoietin 2 [17]. The gene discussed is VEGFA; the disease is liver dysplastic nodule.