Given our identification of discrete sets of mRNAs induced by L-SUL in PD and Control hONS cells, including MAFF induction by L-SUL being restricted to PD cultures (Fig 6A), it is possible that altered NRF2-small MAF heterodimer formation is driving the differential expression of genes within the NRF2 pathway in hONS cells. Here, MAFF is linked to Parkinson disease.