Of particular interest are: (i) angiotensin II (Ang II), one of the main regulators of blood pressure and Na+ reabsorption [19], is a potent activator of the Na+-ATPase [20]; (ii) all components of the signal cascade that link Ang II receptors (AT1 and AT2 receptors) form a functional complex with the neighboring Na+-ATPase in basolateral membranes of kidney proximal tubule cells [20], [21], [22]; (iii) Overactive renal Na+-ATPase is one of the main molecular findings in obesity-associated hypertension [17] and in spontaneously hypertensive rats [23]. This evidence concerns the gene AGT and obesity due to melanocortin 4 receptor deficiency.