Interestingly, a cancer-associated cysteine-to-phenylalanine point mutation in the zinc finger domain of Mdm2 disrupts binding of L11 and L5 to Mdm2 [10], and Mdm2C305F mutant knock-in mice are deficient in p53 induction in response to induced ribosomal stress [11]. This evidence concerns the gene TP53 and cancer.