The ability of Myc to promote cell growth and proliferation is closely linked to its role in regulating ribosomal biogenesis, and in the case of Mdm2C305F and Myc-induced lymphoma, ribosomal protein expression is elevated, however ribosomal proteins L11 and L5 are unable to bind and suppress Mdm2C305F, resulting in attenuation of p53 activation [11]. The gene discussed is RPL11; the disease is lymphoma.