GLIS3 and Insulin resistance: More recently, a large genome-wide meta-analysis of data from 21 GWAS in populations of European origin identified a common variant near IGF1 associated with hyperinsulinemia and insulin resistance (HOMA-IR), and nine novel loci (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, PROX1, SLC2A2, C2CD4B) influencing fasting glucose [6].