To examine whether impaired beta-cell function (HOMA-B) or insulin resistance (HOMA-IR) mediates the associations of GLIS3-rs7034200 with type 2 diabetes and/or combined IFG/type 2 diabetes, we re-evaluated the associations in multivariate model (adjusting for family history of diabetes, lipid profile, medication information, hypertension and life-style factors) with further adjustment for HOAM-B or HOMA-IR. Here, GLIS3 is linked to Insulin resistance.