There are now several compounds in various stages of preclinical or clinical development for the treatment of T2DM that utilize the GLP-1 signaling pathway; these include GLP-1 receptor agonists with extended half-lives and DPP-4i that increase circulating levels of endogenous, intact, and bioactive GLP-1 [10]. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.