Even in subgroup meta-analyses based on the new definition of drug resistance by International League Against Epilepsy (ILAE)[15] and ethnicity, to address the issue of different definitions of drug responsiveness and drug resistance in the patients with various ethnicities, did not show any association under all genetic models.[10] Hence, in view of these data, we may have to revise the role for ABCB1 gene in epilepsy and more importance must be attributed to its role in tissue defense in epileptic tissue. This evidence concerns the gene ABCB1 and epilepsy.