UGT1A1 and Gilbert syndrome: Approximately 5%–10% of individuals have decreased bilirubin-conjugating activity that is caused by a TA insertion into the UGT1A1 promoter (Gilbert syndrome).[45, 46] The HIV protease inhibitors indinavir and atazanavir commonly cause unconjugated hyperbilirubinemia by competing with bilirubin for binding to UGT1A1.