Since COX-2 and GRPR both regulate cellular processes that contribute to the progression and metastatic spread of prostate cancers and, because BBS has been shown to regulate COX-2 expression in cells from other tissues [27-29], we reasoned that GRPR activation and COX-2 expression may be mechanistically linked in prostate cancer cells. The gene discussed is PTGS2; the disease is prostate carcinoma.