PDLIM2 and colonic neoplasm: In support of this, PDLIM2 expression is epigenetically repressed in several tumors such as breast and colon cancers, and expression of exogenous PDLIM2 or re-induction of endogenous PDLIM2 inhibits constitutive NF-κB activation and suppresses in vitro anchorage-independent growth and in vivo tumor formation of those malignant cells [253,254].