Higher concentrations of salivary IL-6 and TNF-α in oral cancer patients and in patients with oral precancerous lesions were reported by Rhodus et al. (17,18) Saheeb Jamee et al. reported significantly higher salivary IL-6 concentrations in oral cancer patients compared to healthy controls whereas no significant differences in salivary TNF-α between the two groups could be found (19). Here, IL6 is linked to lip and oral cavity carcinoma.