Although none of them except p53 had previously been linked to senescence or known to be downstream effectors of the p53-p21 and p16-pRB tumour suppressor pathways, directly silencing four of these candidates, TMEM9B, ATXN10, LAYN and LTBP2/3 bypassed senescence in CL3EcoR cells. This evidence concerns the gene LTBP2 and neoplasm.