PARK7 and Parkinson disease: We have shown that administration of DJ-1 protein dramatically reduced dopaminergic cell death and restored locomotion defect in PD model rats into which 6-hydroxydopamine (6-OHDA) had been injected [20] and that intrastriatal injection of DJ-1 markedly reduced infarct size in cerebral ischemia in rats [21], suggesting that DJ-1 is a pharmaceutical target for PD and cerebral ischemia.