CD4 and HIV infectious disease: It is also a reliable marker of HIV infection and its progression, and of failure of antiretroviral therapy.2, 6, 7 It is also related (like oral candidiasis) with decreased levels of circulating CD4 cells in HIV seropositive patients.6, 9 It should be noted that this is not an exclusive disease of HIV seropositive patients; it may occur in other immune suppressive states or even in subjects with intact immune systems.10