A well established factor for this infection is a decrease in circulating CD4+ T lymphocytes.2, 4, 5, 6 Candidiasis is considered as a marker of failure of antiretroviral therapy with or without protease inhibitors.2, 7 The three most common forms of candidiasis in the mouth of HIV infected patients are the pseudomembranous form, the erythematous form, and angular cheilitis.5 The gene discussed is CD4; the disease is infection.