A recent study from Desrosier's group demonstrated a clear association between polymorphisms in the IRAK-4 gene and serum IgE levels in patients with chronic rhinosinusitis (CRS) and asthma, indicating IEAK-4 may be important in the regulation of IgE levels in patients with inflammatory diseases of the airways [15]. The gene discussed is IGHE; the disease is chronic rhinosinusitis.