Following RIG-I inhibition, it was seen that phosphoIKKα/β, FADD, IPS-1, TRAF 6 and active Caspase 8 levels were significantly reduced 24 h post infection when compared to only JEV-infected or JEV+Sc-MO group (p<0.05) , while the level of IκBα was significantly increased (p<0.05) (Fig. 3). The gene discussed is CASP8; the disease is infection.