Several association studies have reported that the NFκB1 and NFκBIA polymorphisms is related to the development of inflammatory and other diseases including ulcerative colitis, Graves' disease, and diabetes mellitus, and susceptibility to tumors including melanoma, bladder cancer and CRC in different ethnic groups [32], [36], [45], [46], [47], [48]. The gene discussed is NFKB1; the disease is Graves disease.