Furthermore, when we evaluated NFkB1 and NFKBIA polymorphisms in combination, we found that the combined 2758GG and -94ins/ins+del/ins genotype was associated with a significantly increased risk of CRC compared with those without the 2758GG and -94ins/ins+del/ins genotype, and this increased risk was more pronounced among younger than 60 years, women, never drinkers, never smokers, persons with a normal BMI and those with family history of cancer. The gene discussed is NFKB1; the disease is colorectal carcinoma.