To test this hypothesis, we genotyped the NFκB1-94 insertion/deletionATTG and NFκBIA 2758A>G polymorphisms in our ongoing hospital-based case–control study of CRC in a southern Chinese population, and further performed luciferase assays and Western blotting analysis to identify whether genetic variants in NFκBIA alter its gene expressions and functions and thus cancer risk. The gene discussed is NFKB1; the disease is cancer.