In mouse models of autoimmune disease, 1,25(OH)2D3 suppresses Th1 and Th17-mediated inflammation [32], [33], [34], and T cell VDR expression is required for 1,25(OH)2D3-mediated inhibition of experimental autoimmune encephalomyelitis (EAE) [35]. The gene discussed is VDR; the disease is experimental autoimmune encephalomyelitis.