In fact, increased occurrence of brown-like adipocytes within WAT depots is a feature of mouse strains resistant to dietary obesity, such as the A/J strain [43] and reduced adiposity associated with aP2-transgenic expression of Ucp1 is linked to increased energy dissipation in white, but not interscapular brown, adipose tissue [29]. Here, UCP1 is linked to obesity due to melanocortin 4 receptor deficiency.