CCN2 and Alzheimer disease: In our observed low tension-responsive set (Table S4), we identified the upregulation of peptidyl prolylisomerase gene (Pin1), which has been strongly implicated in modification of the pathology of Alzheimer's disease [60], [63]; connective tissue growth factor (Ctgf) whose expression and effects upon cellular morphology and rearrangement are oxygen sensitive [64] and metallothienein (Mt1a), that has been previously shown to control anti-apoptotic mechanisms induced by anoxic/hypoxic conditions [65].