Based on the position of rs2580520, we conjectured that this SNP may regulate the upstream genes of transcription starts by enhancer, such as FCGR1B or NOTCH2. NOTCH2 expression was high in well-differentiated tumours but low in poor-differentiated tumours which might play a tumour-suppressive role in human breast cancer [11]. The gene discussed is NOTCH2; the disease is breast cancer.