ACTA1 and neoplasm: Figure 3 shows a clear tendency indicating that levels of expression of α-SMA and palladin (but not always uPARAP and EDA) stemming from the lower stage I case were modest when compared to the levels observed in 3D cultures from fibroblasts of higher tumor stages (Table S3). Nevertheless, the levels of α-SMA, palladin and uPARAP were distributed with larger variations of expression compared with the more even distribution of EDA expression. Cases showing higher α-SMA and/or palladin did not always correspond to the ones showing higher uPARAP or EDA (Figures 3E-3H).