One of the genes that showed concordant transcriptional alteration in both LMNAK542/K542N and LMNAG608G/+ cells was TWIST2 (also known as DERMO1), a known transcription factor important for osteoblast differentiation [31], whose knock-out mouse models display a cachectic phenotype similar to HGPS, i.e. postnatal failure to thrive, growth retardation, adipose deficiency, and perinatal death [32]. The gene discussed is TWIST2; the disease is Failure to thrive.