Interestingly, two genes, TNFRSF11B and ENPP1, whose mutations are associated with distinct disease phenotypes present in HGPS were found to have opposite transcriptional changes in LMNAK542/K542N and LMNAG608G/+ fibroblasts (Table S3B; [28]). The gene discussed is ENPP1; the disease is Hutchinson-Gilford progeria syndrome.