TNF and Hypoglycemia: Because Twist2 mutant mice also manifest abnormalities in glucose metabolism and storage, evidenced by hypoglycemia and absence of glycogen in skeletal muscle and liver, as well as by elevated transcription of proinflammatory cytokines (TNFα and IL-1β) in skin, skeletal muscle, and cultured skin fibroblasts [32], we wondered if TWIST2 down-regulation could result in similar molecular and biochemical changes in our patient(s).