INS and Insulin resistance: Nonlinear homeostatic model assessment (HOMA2; [40]), using two independent, one year consecutive measurements of fasting insulin, C-peptide, and fasting glucose, revealed decreased insulin resistance (HOMA2-IR<0.5), strongly increased insulin sensitivity (>240%), and decreased β–cell function (<77%) in LMNA K542N homozygotes (Table S5A).