ERK1/2 and p38 signaling pathways as well as FAK, IKK, NF-kappaB-mediated pathways have been shown to mediate the anti-invasive effect of berberine on MDA-MB-231 human breast cancer cells and human SCC-4 tongue squamous cancer cells, respectively [28], [29]. This evidence concerns the gene MAPK3 and breast carcinoma.