In those ALLs with the TEL-AML1 fusion (n = 5) SOX11 was completely unmethylated (Median/IQR = 0.04/0.04) whereas in other subtypes, like BCR-ABL positive (n = 15) or T-ALL (n = 9) SOX11 exhibited a gradient of DNA methylation values, from unmethylated to methylated cases (Median/IQR of 0.49/0.41 and 0.43/0.40, respectively). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.