In addition to CCR5+CD4+CD3+ T-cells and Langerin+CD1a+CD11c+ LCs, additional HIV target cells including DC-SIGN+MR+CD11c+ mDCs, and MR+CD68+ macrophages were also widely distributed in the superficial layer of the endometrial stroma and may thus theoretically be accessible for HIV-infection following sexual intercourse. This evidence concerns the gene CD4 and HIV infectious disease.