However, the participants included in the present trial presented with values of CorAUCtotal in the initial DEX-CRH test before intervention, (Table 2 (12,005±15,506 nmol/l×min/l)) that were higher than values found among healthy individuals without a family history of MDD in the study by Modell et al.[2] (7,773±1,071 nmol/l×min/l) and approaching the values for healthy individuals with a family history of MDD in that study (15064±3947 nmol/l×min/l), suggesting that participants included in our trial were comparable to the participants with a family history of depression in the Modell study. This evidence concerns the gene CRH and depressive disorder.