Accumulating evidence indicates that Nrdp1 promotes ubiquitination and degradation of the epidermal growth-factor receptor family member ErbB3, the gigantic (530 kDa) inhibitor-of-apoptosis protein BRUCE, and Parkin, which have been implicated in the pathology of numerous disorders, including heart valve formation, cancer, Parkinson's disease, and endotoxin shock [5], [6], [7], [8], [9], [10], [11]. This evidence concerns the gene RNF41 and cancer.