In one of the most recent study to evaluate associations between one-carbon metabolism and colon cancer by CIMP/BRAF status, to date, utilizing a nested case-control approach within the Northern Sweden Health and Disease study (190 cases and 1∶2 matched controls) [24], van Guelpen et al. show a lower risk of CIMP-low/CIMP-high colorectal tumors with very low folate levels. The gene discussed is BRAF; the disease is malignant colon neoplasm.