ESR1 and breast cancer: To address this, we computed time-dependent receiver operating characteristic curves (ROC) for miR-210 expression level and several prognostic signatures – the gene expression grade index (GGI) [13], the 70-gene signature (GENE70) [20], the 76-gene signature (GENE76) [12] and the estimated 21-gene recurrence score (RS) [21] - for RFS within 10 years in the ER-positive patients in both the training dataset and the tamoxifen-treated breast cancer dataset (Figures 5A and 5B).