GNAO1 and cancer: It turns out that 13 of these proteins, protein such as TP53, HCK, PIK3R1, and PSMB4, appeared in significant gene lists in various cancer types [48] and 6 (GNAO1, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G) out of 13 were linked to liver cancer.