GAK and Parkinson disease: In addition, NUCKS1 (nuclear casein kinase and cyclin-dependent kinase substrate 1) [16], [20], the HLA (human leukocyte antigen) region [18], GAK (cyclin G associated kinase) [15], [19], BST1 (bone marrow stromal cell antigen 1) [20], [21], and five additional loci [22] have recently been associated with PD.