This recent finding together with the established knowledge that Mendelian mutations in the genes encoding the platelet VWF (Von Willebrand disease, type 2; OMIM: 613554) and its receptor (Bernard-Soulier syndrome; OMIM: 231200) are causative of giant platelets, give biological credence to the observed effects of Pik3cg knockout on the transcription of these platelet genes. Here, VWF is linked to Bernard-Soulier syndrome.