The lymphocyte associated regions containing HLA-B and HLA-C, harbors two genes that have been implicated in multiple GWAS as modifiers of immunological responses, associated with IL-18 levels, HIV-1 control, vitiligo, multiple clerosis, and psoriasis [49], [68], [70], [71], [72], [73], [74], [75], [76]. The gene discussed is IL18; the disease is psoriasis.